Signaling
Transcription factors, cytokines, and receptors that govern the myelocyte stage: what switches the cell on, what pushes it forward, what arrests it.
Lipid mediators made by erythroblasts, the marrow neighbors of the granulocytic series, program neutrophil development.
Review of how cancer rewires emergency granulopoiesis, including expansion of immature neutrophils.
A Znf711-Phf8 transcriptional complex is required for neutrophil development.
CXCL12 on CXCR4 retains neutrophils in marrow; CXCR2 opposes it; CXCR4 dominates.
G-CSF drives release indirectly; downregulation of stromal SDF-1 is a candidate signal.
C/EBP epsilon is required for the promyelocyte to myelocyte transition.
C/EBP epsilon rises as granulocytic differentiation proceeds.
Without G-CSF, marrow granulopoietic precursors fall by 50 percent and blood neutrophils to 20 to 30 percent of normal.
From PubMed
Asking PubMed for every paper on the myelocyte in this section.